Molecular epidemiology of type 1 diabetes in China.
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TextDescription: 300 pISBN: 0493068732Subject(s): Health Sciences, Public Health | Health Sciences, Immunology | Health Sciences, Nutrition | 0573 | 0982 | 0570Dissertation note: Thesis (Ph.D.)--University of Pittsburgh, 2000. Summary: Type 1 diabetes has a very low incidence in China, although the reasons for this have not been well studied. In order to consider some environmental factors associated with type 1 diabetes, a subset of registry cases (N = 292) from China and sex, age, ethnic, and geographically matched controls (N = 496) without diabetes were studied. Local centers throughout mainland China collected questionnaire data regarding medical history, demographics, and environmental exposure, and biologic samples for genetic, immunologic, and C-peptide measures from cases and controls. The cases recruited for study were shown to be representative of the entire Chinese registry population. Type 1 diabetes cases were 47% male, had a mean age of onset of 9.6 ± 3.5 years, and had a mean age of clinic visit of 14.2 ± 4.5 years. Ethnic origin of cases was 97% Han, 1.4% Mongol, 1.0% Hui, and 0.7% Man. Based on fasting C-peptide tests and evaluation of immunologic markers (GAD and IA-2) of type 1 diabetes, our sample of registry cases were determined to have autoimmune type 1 diabetes. Socioeconomic group and birth cohort were strongly related to food consumption in infancy for both cases and controls. SES was lower in cases compared to controls (38% low, 54% medium, 8% high vs. 26% low, 66% medium, 8% high; p < 0.01). In multivariate logistic regression analyses which controlled for SES, birth year, and breastfeeding status, soy formula consumption from 6–12 months of age was a risk factor for type 1 diabetes (OR = 1.44; 95%CI: 1.01–2.05; p < 0.05) and steamed bread consumption at 4–6 (OR = 0.65; 95%CI: 0.45–0.94; p < 0.05) and 6–12 months of age (OR = 0.54; 95%CI: 0.38–0.77; p < 0.001), fish consumption at 6–12 months of age (OR = 0.63; 95%CI: 0.42–0.95; p < 0.05), and noodle consumption at 6–12 months of age (OR = 0.60; 95%CI: 0.39–0.91; p < 0.05) were protective for type 1 diabetes. More cases were
Source: Dissertation Abstracts International, Volume: 61-12, Section: B, page: 6426.
Adviser: Janice S. Dorman.
Thesis (Ph.D.)--University of Pittsburgh, 2000.
Type 1 diabetes has a very low incidence in China, although the reasons for this have not been well studied. In order to consider some environmental factors associated with type 1 diabetes, a subset of registry cases (N = 292) from China and sex, age, ethnic, and geographically matched controls (N = 496) without diabetes were studied. Local centers throughout mainland China collected questionnaire data regarding medical history, demographics, and environmental exposure, and biologic samples for genetic, immunologic, and C-peptide measures from cases and controls. The cases recruited for study were shown to be representative of the entire Chinese registry population. Type 1 diabetes cases were 47% male, had a mean age of onset of 9.6 ± 3.5 years, and had a mean age of clinic visit of 14.2 ± 4.5 years. Ethnic origin of cases was 97% Han, 1.4% Mongol, 1.0% Hui, and 0.7% Man. Based on fasting C-peptide tests and evaluation of immunologic markers (GAD and IA-2) of type 1 diabetes, our sample of registry cases were determined to have autoimmune type 1 diabetes. Socioeconomic group and birth cohort were strongly related to food consumption in infancy for both cases and controls. SES was lower in cases compared to controls (38% low, 54% medium, 8% high vs. 26% low, 66% medium, 8% high; p < 0.01). In multivariate logistic regression analyses which controlled for SES, birth year, and breastfeeding status, soy formula consumption from 6–12 months of age was a risk factor for type 1 diabetes (OR = 1.44; 95%CI: 1.01–2.05; p < 0.05) and steamed bread consumption at 4–6 (OR = 0.65; 95%CI: 0.45–0.94; p < 0.05) and 6–12 months of age (OR = 0.54; 95%CI: 0.38–0.77; p < 0.001), fish consumption at 6–12 months of age (OR = 0.63; 95%CI: 0.42–0.95; p < 0.05), and noodle consumption at 6–12 months of age (OR = 0.60; 95%CI: 0.39–0.91; p < 0.05) were protective for type 1 diabetes. More cases were
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